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Category:Web mailInhibition of Tumor Vascularization by Lactobacillus Sp. Bifidobacterium Adheres to the Human Microvascular Endothelial Cell Line HMEC-1.
In the present study, the effects of six lactic acid bacteria (LAB) strains (Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus paracasei subsp. paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus GG, and Bifidobacterium bifidum) were investigated on the cell migration and proliferation of the human microvascular endothelial cell line HMEC-1. In addition, the influence of these bacteria on human umbilical vein endothelial cells and skin fibroblasts was also evaluated. In the migration assay, the number of cells after treatment with the LAB strains was significantly higher than that of the control. The proliferation assays revealed that only B. bifidum and L. fermentum significantly increased the number of cells in comparison to the control. This study revealed the positive influence of the bacteria on HMEC-1 cells and the underlying mechanism. Since HMEC-1 cells are known to mimic the in vivo vascular endothelium, the results can be confirmed by in vivo studies.

 

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