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Category:Musical groups from BarcelonaSelecting subclinical at-risk animals for colorectal cancer testing.
The clinical and economic benefits of preventive colorectal cancer (CRC) screening in humans are well established, and screening programmes are now widely available in the developed world. In contrast, in the developing world, few CRC screening programmes exist, but there is growing evidence that the incidence of CRC is increasing in these areas. Preventive strategies to control or eradicate CRC in people are therefore unlikely to be sustainable in the long term. Therefore, the focus for developing countries should be on the detection of CRC in its early stages so that it can be treated by surgeons or endoscopists as an elective surgical procedure, rather than as a life-threatening emergency. This is possible with the development of screening programmes for the population as a whole, with a high sensitivity and specificity, but also by selecting at-risk individuals using the use of biomarkers for CRC detection. Biomarkers can detect neoplasia or other abnormal mucosal changes with high specificity, and may be classified as tumour or host-related markers. Current data suggest that the identification of host-related markers, such as Fusobacterium nucleatum (F. nucleatum) and sialic acid-binding immunoglobulin-like lectin 9, may be a promising approach for population-based screening. In this chapter we review the evidence that suggests that CRC screening with these biomarkers may be feasible in the developed world, and discuss the approaches for screening populations at-risk for CRC in developing countries.

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