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Combination antiretroviral therapy (cART) for HIV-1 infection has reduced the incidence of perinatal transmission of HIV-1. However, reduced adherence during pregnancy has been reported to be associated with an increased risk of perinatal HIV-1 transmission. Since adherence is a major determinant of virological outcome, treatment regimens that enhance adherence are important to prevent perinatal HIV-1 transmission. cART is generally well tolerated during pregnancy and potentially associated with a reduction in adverse maternal and perinatal outcomes. However, there is a lack of evidence on the efficacy and tolerability of cART in pregnancy. In this review, we discuss the current knowledge on the safety and efficacy of cART during pregnancy in the light of the studies performed in the last few years.# From

md_panel_theme = panel_theme_md_theme

md_tab_panel_theme = tabPanel_theme_md_theme

ggplot2_theme = theme_ggplot2() +

theme(panel.grid.major = element_blank(),

panel.grid.minor = element_blank(),

panel.background = element_blank(),

plot.background = element_blank(),

strip.background = element_blank(),

strip.text = element_text(size = 20, face = “bold”),

axis.text.x = element_text(size = 20, angle = 45, hjust = 0.5, vjust = 1),

axis.text.y = element_text(size = 20, angle = 45, hjust = 0.5, vjust = 1),

axis.title.x

 

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