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Photographer: Dave Martin/Bloomberg Photographer: Dave Martin/Bloomberg

For the second time in less than two years, Pfizer Inc. will try to break the $100-a-share barrier, according to people familiar with the matter.

The new offering would come on top of three large, initial public offerings from drugmakers this year, as U.S. companies prepare to compensate shareholders with more money. The deals include $13 billion from UnitedHealth Group Inc., $15 billion from Allergan Plc and $11.5 billion from Turing Pharmaceuticals.

Expectations of huge pricing increases in a new drug market have fueled the wave of stock offerings, now reaching $60 billion. Pfizer’s offering, however, is valued at $100 billion, making it the most expensive in the history of the stock market.

“Pfizer’s effort to go public would be the largest IPO in history,” Jonathan Smucker, president of the U.S. IPO division at UBS AG, said in a report Thursday. “As a result, it’s almost certain to be a bidding war.”

Pfizer is in the midst of a $40-billion acquisition of Wyeth and could use the proceeds from the sale to help pay for the deal, according to people familiar with the matter. It’s unclear when the company could put its plans to go public before regulators and investors.

The company is in talks with Morgan Stanley to act as underwriter, according to people familiar with the matter, and is planning a mid-November or December IPO.

The deal would come at a time when the market is turning bullish. Eight of the 12 largest drug companies by market value, including Pfizer, are expected to report earnings gains in the current quarter. Pfizer shares are down 8 percent since the start of the year.

Morgan Stanley declined to comment. 0x79, 0x4b, 0x1e, 0x5b, 0x5a, 0x72, 0x1a, 0x6d, 0x14,

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