Gx Works 2 198 14 [Updated] 2022

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Gx Works 2 198 14

 

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Toxins are present in all living organisms and contribute significantly to human mortality and morbidity. Increasing scientific interest in the biological activity of a class of diverse toxins and the biochemical nature of their cellular targets has resulted in the discovery of a unique number of macromolecules, including enzymes, DNA, RNA, lipids, proteins, and small molecules, which are recognized as the molecular targets of different kinds of toxins. This review addresses the various mechanisms of action of toxins on their cellular targets and includes an overview of the different types of toxins. A list of different toxins with their biological targets is shown in Table 1.

A number of different types of bacterial toxins have been studied. These include those that act on the cell membranes of eukaryotic cells such as cholera and shiga toxins, those that act on DNA such as anthrax and CTX, and those that act on the RNA such as the Q-rich toxin of E. coli and H-antigens of Clostridium botulinum. Although these toxins have a number of common properties, their mode of action is highly diverse. The biological activity of bacterial toxins is often investigated using genetically modified bacteria which produce specific toxins in a controlled manner. In this way, the toxicity of the toxin can be examined under various conditions in a cell-free environment.

3 A minor protein can be recognized by the host defence mechanism and can thus induce the synthesis of cytokines (also called pyrogen) which may induce fever. Usually, the minor protein is inactivated by either a proteolytic or peptidase activity within the host. The most important pyrogen is the proteinaceous endotoxin of Gram-negative bacteria. The inflammatory response consists of the induction of the production of the cytokine tumor necrosis factor (TNF) by the macrophages as a key factor.

4 FtsX, a cytoplasmic protein, is necessary for full replication of the bacterial chromosome. FtsX may interact with the membrane of the septal region, the cytoplasmic membrane and the cytoplasm. The membrane anchor, the hydrophobic N-terminal region and the hydrophilic C-terminal region make FtsX a very interesting

 

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