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Category:1991 video games
Category:Amiga games
Category:Amiga 1200 games
Category:DOS games
Category:Formula One video games
Category:Sega Game Gear games
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Category:Video games developed in the United KingdomPeripheral blood T-cell subpopulation in Graves’ disease.
In Graves’ disease, a defect of antigen-induced T-cell activation has been suggested, but the influence of the T-cell repertoire on the expression of clinical signs and symptoms of the disease is not clear. Therefore, we investigated the peripheral blood T-cell subpopulation (T-helper, T-suppressor, and T-cytotoxic cells) of 14 patients with Graves’ disease. Before and after therapy, peripheral blood mononuclear cells (PBMC) were purified and then stained with monoclonal antibodies (MoAbs) of the OKT series. T-helper cells were defined as OKT4+, T-suppressor cells as OKT8+, and T-cytotoxic cells as OKT3+ and OKT8+ (as OKT3+). The percentage of T-helper cells in patients was normal, but patients with serum immunoglobulin M (IgM) exceeding 2000 mg/L, high radioactivity uptake (RAU) of the thyroid, and the goiter score (GS) greater than 10 before therapy showed a significant decrease of T-helper cells after therapy. There was a negative correlation between the T-helper cells before and after therapy (P less than.01). On the other hand, T-suppressor cells were increased significantly and showed a positive correlation with the serum level of IgG (P less than.01). T-cytotoxic cells did not show any change. These results indicate that a disorder of the T-helper subpopulation may exist in Graves’ disease.Aggie Sharp



Birthday: June 19, 1975

Where you’re from: Worthing, England

What you’ve done before: She appeared in a short film, but is best known as a member










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